Our has identified a function for kinetochore proteins in the branching morphogenesis of PVD, an established model to study dendritic branching and regeneration. It was recently discovered that microtubule binding components of the kinetochore, the mitotic protein machinery that segregates chromosomes have an essential post-mitotic role in dendrite morphogenesis & regeneration (Cheerambathur et al., 2019 Hertzler et al., 2020).
Our lab is interested in analysing the role of cytoskeletal proteins in neuronal morphogenesis (Cheerambathur et al., 2019). In this project we will assess the molecular factors responsible for dendritic branching of the the nociceptive receptor neuron, PVD in the small animal model, C. The mechanisms that underlie the elaborate branching of dendrites and their maintenance during the lifetime of an organism is not well understood. These neurons are characterized by their elaborate dendritic arbors that reach out to sense the stimuli. Nociceptive receptor neurons are dedicated peripheral sensory neurons that detect external stimuli such as touch, temperature etc (Hall & Treinin, 2011). Neurons are specialized electrically excitable cells that transmit their signals using their two distinctive functional domains, the dendrite and axon. We can still accept applications for this project from self-funding students. **PLEASE NOTE – the deadline for requesting a funding pack from Darwin Trust has now passed and completed funding applications must be submitted to Darwin Trust by 19th January.
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